Yeast Eco1 (ESCO2 in humans) acetyltransferase converts chromatin-bound cohesins to a DNA tethering state. thereby establishing sister chromatid cohesion. Eco1 establishes cohesion during DNA replication. after which Eco1 is targeted for degradation by SCF E3 ubiquitin ligase. https://allfixelectricales.shop/product-category/fast-freeze-cover-clip/