Osteogenesis Imperfecta is a hereditary connective tissue disorder due to COL1A1/2 mutation causing gene defect encoding proteins to metabolize collagen. The skeletal manifestation of OI causing bone incompetence. hence the name brittle bone disease. Here we report three cases of OI type IV in adults. https://www.diegojavierfares.com/quick-buy-Hamamelis-Crema-50g-big-deal/